Therapeutic hypothermia for acute brain injuries
نویسندگان
چکیده
منابع مشابه
Therapeutic hypothermia for acute brain injuries
Therapeutic hypothermia, recently termed target temperature management (TTM), is the cornerstone of neuroprotective strategy. Dating to the pioneer works of Fay, nearly 75 years of basic and clinical evidence support its therapeutic value. Although hypothermia decreases the metabolic rate to restore the supply and demand of O₂, it has other tissue-specific effects, such as decreasing excitotoxi...
متن کاملTherapeutic Hypothermia for Brain Ischemia
Mild hypothermia is an established neuroprotectant in the laboratory, showing remarkable and consistent effects across multiple laboratories and models of brain injury. At the clinical level, mild hypothermia has shown benefits in patients who have experienced cardiac arrest and in some pediatric populations experiencing hypoxic brain insults. Its role, however, in stroke therapy has yet to be ...
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We describe a 65-year-old man who presented to the emergency department with acute cerebral air embolism after receiving computed tomography guided lung biopsy. The patient presented with muscle strengths of 0/5 in left arm and 3/5 in left leg, aphasia, and a right pneumothorax. Our concern was to improve the patient’s neurological function, while ensuring stability in a patient who possibly ha...
متن کاملTherapeutic hypothermia for acute ischemic stroke.
Intravenous recombinant tissue plasminogen activator remains the only US FDA-approved treatment for acute ischemic stroke. However, the very limited time window for its administration restricts its usefulness. Furthermore, it is becoming increasingly clear that, given the numerous pathways via which cerebral ischemia causes cell death, the capacity to inhibit multiple mechanisms simultaneously ...
متن کاملTherapeutic Hypothermia in Acute Stroke
Stroke is the second most common cause of death and a major cause of serious long-term disability in adults in industrialized countries. Approximately 90% of strokes are ischemic and the rest are hemorrhagic.[1] Unfortunately, few effective treatments can be offered during the acute and subacute phases. Since the introduction of tissue plasminogen activator (tPA) in 1995, there are no other med...
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ژورنال
عنوان ژورنال: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
سال: 2015
ISSN: 1757-7241
DOI: 10.1186/s13049-015-0121-3